Serum kynurenic acid positively correlates with cardiovascular disease risk factor, homocysteine: a study in stroke patients.

摘要: KYNA, an antagonist of ionotropic glutamate receptors and alpha7 nicotinic receptors, has been found as well in the brain periphery. The altered metabolism especially its deficiency, can lead to enhanced glutamate-mediated excitotoxicity, was suggested be a factor contributing development neurodegeneration seizures. Elevated serum concentration homocysteine is considered independent risk atherosclerosis emerging cognitive dysfunction stroke. In present study, level other biochemical parameters were assessed patients at early (up 24 h after infarct) stage Serum KYNA levels similar control (N = 26) stroke 24) groups. correlated positively with group, p 0.018; r 0.462 0.027; 0.451, respectively. also age (p 0.007; 0.514) creatinine 0.002; 0.581). 0.001; 0.644) urea < 0.716). Homocysteine inversely folate 0.01; -0.499) but not group 0.13; -0.317). 0.6401), 0.017; 0.4813). Clinical significance association between requires further investigation.