Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice.

摘要: Abstract Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental that affects 8–12% of children globally. Factor analyses have divided ADHD symptoms into two domains: inattention and combination hyperactivity impulsivity. The identification domain-specific genetic risk variants may help uncover potential mechanisms underlying ADHD. We previously identified thyroid hormone-responsive (THRSP) gene expression upregulated in spontaneously hypertensive rats (SHR/NCrl) Wistar-Kyoto (WKY/NCrl) which exhibited behavior. Thus, we established line THRSP overexpressing (OE) mice assessed their behavior through an array behavioral tests. protein overexpression the striatum (STR) was confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) western blotting. OE novel-object recognition Y-maze test, but not open-field test impulsivity cliff-avoidance delay-discounting task. also found dopamine-related genes (dopamine transporter, tyrosine hydroxylase, dopamine D1 D2 receptors) STR increased. Treatment with methylphenidate (5 mg/kg), most commonly used medication for ADHD, improved attention normalized levels mice. Our findings suggest plays role phenotype be as animal model to elucidate disorder.