Acceleration of Fetal Lung Maturation by Aminophyllin in Pregnant Rabbits

摘要: Extract: To test the hypothesis that fetal lung maturation can be accelerated by one of xanthine derivatives, aminophyllin was given to 40 pregnant rabbits beginning on 20th gestational day for a period 7–10 days. The fetuses were delivered cesarean section and maturity assessed determining biochemical, functional, ultrastructural characteristics aminophyllin-treated vs. control animals. phospholipid content tissue homogenate from group significantly higher than in subjects (saline injected) at 28 days gestation (421 ± 9 368 12 μg/mg wet wt, mean SEM) 29 (531 10 475 20). alveolar wash 30 (167 dry SEM 117 17). compliance derived pressure volume curves also when compared with controls 27 (0.023 0.0005 ml/cm H2O, vs 0.010 0.0002) (0.048 0.0003 0.035 0.0006). There no significant difference number lamellar bodies type II cells between groups. data show has accelerating effects drug is during last 7-10 gestation. Speculation: Our do not permit extrapolation into clinical application utilizing derivatives enhancement maturation. However, they provide evidence there may several pharmacologic agents might enhance various mechanisms. These impetus some centers review statistical correlation respiratory distress syndrome infants born mothers who have received latter part pregnancy treatment such conditions as bronchial asthma. If positive one, it justified initiate trial evaluate effect derivative mother purpose preventing newborn infant.