Comparison of the Effect of Electrical Stimulations on the Chin Skin on Autonomic Nervous Activities During Propofol Sedation With or Without Midazolam

摘要: Purpose The aim of this study was to compare the effect electrical stimulations on chin skin autonomic nervous activities evaluated by use power spectrum analysis heart rate (HR) variability during intravenous sedation using propofol with or without midazolam. Materials and Methods Thirty-eight healthy adult male volunteers underwent midazolam (group MP) alone P) in a randomized crossover manner. In group MP, participants received (0.04 mg/kg) target-controlled infusion predicted blood concentration 1.0 μg/mL. P, maintained at 1.5 μg/mL. observed variables were bispectral index value, systolic pressure, HR, high-frequency component (HF), low-frequency (LF), LF/HF ratio. Measurements conducted over 100-second periods carried out before, during, after emergence from administering 0.2 mg flumazenil. paired t test, Wilcoxon repeated-measures variance, Friedman χ 2 r test used for statistical analyses. Results mean age body weight 24.6 ± 2.8 years 67.0 7.9 kg, respectively. Bispectral values, HR showed similar changes both groups. ratio MP lower than that before sedation; it also P sedation. Conclusions Intravenous combination inhibited sympathetic activation induced greater extent alone.