Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs.

摘要: In the current era of antiviral drug therapy, combining multiple drugs is a primary approach for improving effects, reducing doses individual drugs, relieving side effects strong and preventing emergence drug-resistant viruses. Although variety new have been developed HIV, HCV influenza virus, optimal combinations are incompletely understood. To optimize benefits multi-drugs combinations, we must investigate interactions between combined their target Mathematical models viral infection dynamics provide an ideal tool this purpose. Additionally, whether computed by these synergistic can be assessed two prominent combination theories, Loewe additivity Bliss independence. By mathematical modeling virus with could show principles which yield effect. Here, describe theoretical aspects therapy discuss application to research.