Cellular signaling pathways and transcriptional regulation in Mycobacterium tuberculosis: Stress control and virulence

摘要: Mycobacterium tuberculosis is a successful pathogen that overcomes the numerous challenges presented by immune system of host. This bacterium usually establishes chronic infection in lun g where it may silently persist inside granuloma until failure host defenses can lead to reactivation disease. An increasing number molecular genetic tools available past few years have made possible study signal transduction and transcriptional regulatory mechanisms contribute ability M. be so well adapted. review intends summarize current knowledge about major components involved signaling pathways transcription al regula tion with specific emphasis on their relation bacterial pathogenesis cope stresses