NIH workshop report on the trans-agency blood–brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface

摘要: A trans-agency workshop on the blood–brain interface (BBI), sponsored by National Heart, Lung and Blood Institute, Cancer Institute Combat Casualty Care Research Program at Department of Defense, was conducted in Bethesda MD June 7–8, 2016. The structured into four sessions: (1) blood sciences; (2) exosome therapeutics; (3) next generation vitro barrier (BBB) models; (4) BBB delivery targeting. first day focused physiology neuro-vascular unit, or biofluid-based molecular markers, extracellular vesicles associated with brain injury, how these entities can be employed to better evaluate injury states and/or deliver therapeutics. second technical advances models, manipulations nanoparticle-based drug carrier designs, goal improving central nervous system. presentations discussions underscored role BBI as well both a limiting factor potential conduit for brain. At conclusion meeting, participants discussed challenges opportunities confronting translational researchers. In particular, recommended using research stimulate diagnostics, targeted approaches detection therapy disease.