Conditioned increase in place preference by access to novel objects: antagonism by MK-801

摘要: In three separate place conditioning experiments with rats, repeated access to novel objects in one of two distinct environments conditioned an increase preference for the novelty-paired environment. A was found whether were paired a randomly chosen environment or less preferred (conditioned against preference). This enhanced did not depend on control group employed. Control groups exposed only apparatus both and showed no systematic shift preference. Intravenous infusions cocaine also produced using procedures employed objects. Pretreatment N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 (0.03 mg kg−1) blocked acquisition by without decreasing time spent inducing aversion controls. Combined, these results show that can serve as appetitive stimulus like drugs abuse this novelty-induced process involves NMDA receptors. These place-conditioning may provide good model determining behavioral neural underlying effects novelty.