Assessment of inflammation and nutrition in patients with end-stage renal disease.

摘要: Malnutrition commonly occurs in patients with end-stage renal disease (ESRD), and hypoalbuminemia is considered the best clinical marker of malnutrition mortality this population. Recently, it has been recognized that a substantial number ESRD have serologic evidence an augmented inflammatory response moreover, inflammation may be as or more important than protein intake causing hypoalbuminemia. In addition, presence powerful predictor dietary intake. The often subtle detected by increased levels positive acute phase proteins, most notably C-reactive protein. causes stimulation systemic include reaction to dialyzer membranes, production advanced glycosylated end-products, oxidative stress uremia overt occult infections, especially unrecognized arteriovenous graft infections. There complex relationship between nutritional status. Inflammation can cause both anorexia protein-calorie well wasting through mechanisms mediated cytokines. Novel therapies will need developed counter since appears major disease.