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摘要: It is well established that epigenetics and chromatin modifications are primary factors can govern gene activity nuclear architecture. They also proven to be essential for normal embryonic development cell differentiation. One important step during mouse the establishment of epigenetic reprogramming which believed vital growth development, however; mechanism still poorly understood. Creating embryo using reproductive biotechnology such as IVM/IVF, ICSI transfer may cause abnormal pattern. This review summarise role importance in from research literature mainly used a model mammalian development.