作者: Alessandra Graziottin
DOI: 10.3109/13625187.2015.1077380
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摘要: Objectives The menstrual cycle is characterised by cyclical fluctuations in oestrogens, progesterone and androgens. Changes hormone levels the premenstrual phase with decline trigger a physiological reaction which culminates menstruation. This process accompanied many women various symptoms such as pelvic pain, headache, mood disorders gastrointestinal discomfort. aim of this article was to summarise latest findings on physiology pathophysiology menstruation review impact shortening hormone-free interval (HFI) health wellbeing women.Results Menstruation can be viewed an inflammatory event local systemic effects produce genital extragenital regions body. mast cells are main mediator reaction. In using hormonal contraceptives, bleeding not biologically necessary it may advantageous maintain more stable progesterone...