Cell differentiation and its relation to promotion and prevention of bladder cancer.

摘要: There are many ways of considering the biogenesis cancer, partly because it is not a single entity but family diseases all which characterized by uncontrolled, atypical cell growth. While generally accepted that neoplastic reflects an altered function genome, initial injury to genetic apparatus may be quite different in cancers. Some neoplasms associated with gross morphological alterations chromosomes, for example familial retinoblastoma; others, growth follows incorporation viral genome into suppresses does eliminate genes controlling normal differentiation, as seen transformation human cells culture SV 40 virus. Indeed, there no permanent tumor instead only selection those expressed, indicated production chimeric mice from teratocarcinoma demonstrated Dr Mintz and Illmensee (for review recent work see paper this volume). In instances, however, final result phenotype, such cancer express certain properties differ they were derived. Thus maybe regarded disease necessarily certainly some concomitant phenotypic change differentiation obligatory.