Gender-related protection from or vulnerability to severe CNS diseases: Gonado-structural and/or gonado-activational? A meta-analysis of relevant epidemiological studies

摘要: Abstract Background A vast scientific literature has dealt with gender-specific risk for brain disorder. That field is evolving toward a consensus to the effect that estrogen hormone family outstandingly and uniquely neuroprotective. However, epidemiology relevant this general outlook remains piecemeal. Method The present investigation strategically formats epidemiological findings around world in order quantitatively meta-analyze gender ratio of variety severe central nervous system (CNS) diseases at all three gonadal stages life cycle, pre pubertal, post adolescent/pre menopausal, menopausal. Results data establish (1) no single study should be cited as evidence neuroprotection against most common CNS because ratios are contradictory from one other; (2) disease indeed significantly gender-specific, but either can protected: it depends on disease, not age bracket. Conclusion Our assay been able support idea according which any gender-prevalent steroid dominates neuroprotective agent natural concentrations.