The Morphological Approach to the Study of Normal and Abnormal Brain Permeability

摘要: The rich capillary bed of the central nervous system (CNS) is impervious to protein. This generalization derives from two observed features cerebral wall: (a) tight junctions between contiguous endothelial cells comprise uninterrupted belts that arrest passive, intercellular movement protein and (b) vesicles bud off cell membrane do not appear carry across blood perivascular tissue19. We would like review briefly where how this blood-brain barrier (BBB) peptide circumvented in normal experimentally manipulated mammal. It will become apparent some vessels which are naturally permeable or rendered experimentally, one other both altered: open no longer plasmalemma certain capable vesicular transport. A third means bypassing must still be considered as a strong suspicion rather than proven: fenestrae round windows perforate attenuated endothelium capillaries few specific regions bridged by thin diaphragms may peptide. fourth bypass we have just come appreciate: very axons neurons within parenchyma. through cytoplasm these large molecules can brought extracerebral, peripheral neuronal bodies brain spinal cord6.