Abnormality of blood coagulation indexes in patients with de novo acute leukemia and its clinical significance

摘要: To explore hemorrhage risk and the clinical significance of abnormal change prothrombin time (PT), activated partial thromboplastin (APTT), plasma fibrinogen (FIB), thrombin (TT) d-dimer (D-D) in de novo acute leukemia (except for APL), different bleeding manifestations 114 cases with coagulation indexes were analyzed retrospectively. The correlation between these blood possible correlative characteristics analysed, including age, sex, type leukemia, initial white cell(WBC) platelet(Plt) count, proportion blast cells bone marrow cytogenetic abnormality patients at diagnosis. results indicated that incidence was as high 78.1% AL patients. These 5 normal may have mild manifestation, but more indexes, severe bleeding. Both PT D-D sensitive diagnosis level II Incidence significantly correlates (χ(2) = 4.184, OR 1.021, P < 0.05) (P 0.01), while AL, WBC Plt count cytogenetics did not correlate coagulation. It is concluded fibrinolysis are most leukemia. More indicate bleeding, both Higher predicts higher clotting. Acute elderly cell adverse do predict severer Detection PT, APTT, TT, FIB, help to judge whether a state hypercoagulability or disseminated intravenous coagulation, which will provide experiment evidences early intervention medication.