Platelet and erythrocyte Mg2+, Ca2+, Na+, K+ and cell membrane adenosine triphosphatase activity in essential hypertension in blacks.

摘要: Objective: To assess the relationship between intracellular Mg2+, Ca2+, Na+ and K+ cell membrane adenosine triphosphatase (ATPase) activity in normotensive hypertensive blacks. Design: Intracellular cations ATPase were studied black patients with untreated essential hypertension age-, weight- height-matched controls. Platelet, erythrocyte serum levels as well platelet Na+, -ATPase, Ca2+ -ATPase Mg2+-ATPase activities measured all subjects. Methods: by flame photometry Mg+ Ca+ atomic absorption spectrophotometry. Cell was determined a colorimetric method. Results: The group consistently demonstrated depressed of each studied, significantly lower K+, Mg2+ compared group. Platelet elevated In group, mean arterial pressure (MAP) inversely correlated Ca2+-ATPase Mg2+-ATPase. Serum negatively MAP whilst positively correlated. Mg2 + negatively, MAP, Conclusions: Black have widespread depression depletion cytosolic overload, which may reflect an underlying abnormality hypertension. These cellular abnormalities be related to defective transport mechanisms that turn aggravated depletion.