Determinants of Organotropic Metastasis

摘要: The spread of cancer from a primary tumor to distant organ sites is the most devastating aspect malignancy. Dissemination specific organs depends upon blood flow patterns and characteristics environment, such as vascular architecture, stromal cell content, biochemical milieu growth factors, signaling molecules, metabolic substrates, which can be permissive or antagonistic metastatic colonization. Metastatic cells possess intrinsic cellular properties selected for adaptation environments, where they co-opt survival signals, undergo reprogramming, subvert resident activities promote extravasation, immune evasion, angiogenesis, overt growth. Recent work new experimental models organotropism are uncovering crucial details how malignant metastasize tissues, revealing key mediators that prepare niches in identifying...