A comparative perspective on lung and gill regeneration

摘要: The ability to continuously grow and regenerate the gills throughout life is a remarkable property of fish amphibians. Considering that gill regeneration was first described over one century ago, it surprising underlying mechanisms cell tissue replacement in remain poorly understood. By contrast, mammalian lung largely quiescent organ adults but capable facultative following injury. In course past decade, has been recognized lungs contain population stem or progenitor cells with an extensive restore tissue; however, despite recent advances regenerative biology lung, signaling pathways underlie are this Review, we discuss common evolutionary embryological origins shared by lungs. These evident homologies structure, populations, cellular function genetic pathways. An integration literature on vertebrates presented using comparative approach order outline challenges these areas, highlight importance aquatic as model organisms. study amphibians, which have high potential for tools widely available, represents unique opportunity uncover may be important respiratory organs all vertebrates. This lead new repair disease.