Substituted pyridine derivatives

作者: Nikolay Khanzhin , Mario Rottländer , Christian Wenzel Tornøe , William Patrick Watson , Daniel Rodriguez Greve

DOI:

关键词:

摘要: The present invention relates to pyridine derivatives of the general formula (I) and their use as openers KCNQ family potassium ion channels for treatment CNS disorders.

参考文章(58)
Hans Bundgaard, Design of prodrugs Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co.. ,(1985)
Mark S. Hixon, Charles A. Kettner, Hepatitis c protease exosite for inhibitor design ,(2001)
Jean Jacques, André Collet, Samuel H. Wilen, Enantiomers, Racemates, and Resolutions ,(1981)
Steven I. Dworetzky, Christopher G. Boissard, Chandra S. Ramanathan, Valentin K. Gribkoff, Joanne T. Trojnacki, Human kcnq5 potassium channel, methods and compositions thereof ,(2001)
Steven I. Dworetzky, Gene G. Kinney, Pierre Dextraze, Piyasena Hewawasam, Charles D. Weaver, Dharmpal S. Dodd, Valentin K. Gribkoff, 2,4-disubstituted pyrimidine-5-carboxamide derivatives as kcnq potassium channel modulators ,(2002)
Fernando Albericio, Louis A. Carpino, Coupling reagents and activation. Methods in Enzymology. ,vol. 289, pp. 104- 126 ,(1997) , 10.1016/S0076-6879(97)89046-5
Andreas Ritzén, Nikolay Khanzhin, Mario Rottländer, William Patrick Watson, Substituted p-diaminobenzene derivatives ,(2004)
Grant Mcnaughton-Smith, George Salvatore Amato, Paul Christopher Fritch, Pyridine-substituted benzanilides as potassium ion channel openers ,(2002)