Mesoblastic nephroma--a report from the Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH).

摘要: BACKGROUND Surgery alone is the appropriate first-line treatment for patients with mesoblastic nephroma (MN). Nevertheless, there are reports of local recurrences and metastasis, especially in cellular subtype. The authors evaluated outcome MN who were enrolled either International Society Pediatric Oncology (SIOP) 93-01/GPOH or SIOP 2001/GPOH Nephroblastoma Study Trial. METHODS In total, 50 analyzed. Eleven suspected antenatally having a renal tumor. median age at diagnosis was 18.5 days. Central pathologic review performed all specimens. observation time 4.2 years. RESULTS Forty-five underwent initial surgery. Five older than 6 months received preoperative chemotherapy. Twenty-nine tumors classic MN, 21 MN. Nine had Stage III 5 those tumor ruptures, 8 positive surgical margins. After they nephrectomy, 40 no further treatment. For entire group, event-free survival (EFS) (94%) overall (OS) (95%) excellent. Patients 3 older, lower EFS. Three developed recurrent disease, 2 died. Metastases to brain, lung, liver observed 1 patient. CONCLUSIONS Radical nephrectomy accurate surgical-pathologic staging standard care children Nonetheless, subgroup (Stage older) tends develop more often. Further prospective studies will be needed verify this finding should help determine whether these may benefit from adjuvant therapy. Cancer 2006. © 2006 American Society.