Regional haemodynamic responses to infusion of lipopolysaccharide in conscious rats: effects of pre- or post-treatment with glibenclamide

摘要: To determine the putative contribution of KATP-channels to haemodynamic sequelae endotoxaemia, three experiments were carried out in different groups conscious, chronically-instrumented, unrestrained, male Long Evans rats. In first experiment, pretreatment with KATP-channel antagonist, glibenclamide, abolished initial hypotension, but not renal vasodilatation caused by LPS infusion. Subsequently, however, presence glibenclamide and there was a significant increase mean arterial blood pressure, bradycardia, contrast fall pressure tachycardia seen vehicle LPS. The pressor bradycardic changes accompanied reductions hindquarters flow vascular conductance, these significantly greater than those LPS, or saline. Administration 6 h after onset saline infusion, infusion AT1-receptor losartan, ETA-, ETB- receptor SB 209670, absence dexamethasone, renal, mesenteric conductances, although latter only bed which reduction flow. The results are consistent from particularly bed. British Journal Pharmacology (1999) 128, 1772–1778; doi:10.1038/sj.bjp.0702985