Fungal Endocarditis: Evidence in the World Literature, 1965–1995

摘要: We analyzed 270 cases of fungal endocarditis (FE) that occurred over 30 years. Vascular lines, non-cardiac surgery, immunocompromise and injection drug abuse are increasing risk factors. Delayed or mistaken diagnosis (82% patients), long duration symptoms before hospitalization (mean +/- standard deviation, 32+/-39 days) extracardiac manifestations were characteristic. From 1988 onwards, 72% patients diagnosed preoperatively, compared with 43% (P=.0001). The fungi most commonly isolated Candida albicans (24% non-albicans species (24%), Apergillus Histoplasma (6%); recently-emerged accounted for 25% cases. mortality rate was 72%. Survival rates better among who received combined surgical-antifungal treatment, infected Candida, had univalvular involvement. Improvement in the survival (from =4 years while on prophylactic antifungal therapy.