Selection of Self-Reactive T Cells in the Thymus
作者： Gretta L. Stritesky , Stephen C. Jameson , Kristin A. Hogquist
DOI: 10.1146/ANNUREV-IMMUNOL-020711-075035
关键词:
摘要: On the whole, healthy adaptive immune system is responsive to foreign antigens and tolerant self. However, many individual lymphocytes have, even require, substantial self-reactivity for their particular functions in immunity. In this review, we discuss several populations of that are thought experience agonist stimulation through T cell receptor during selection: nTreg cells, iNKT nIELs, nTh17s. We nature self-reactivity, how it compares with conventional why important overall health. also outline molecular pathways unique each lineage consider possible commonalities development survival.
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