What are the structural features of the active site that define binuclear copper proteins function

摘要: The structural basis that define the physiological functions of binuclear copper enzymes is discussed in frame data generated by a broad spectroscopic approach, spanning from paramagnetic NMR and pulsed EPR to x-ray absorption spectroscopies. features for different oxidation ligation states accessible sites are coordination geometry first second shell, metal-metal distance role bridging exogenous ligand(s). A model will be presented rationalize both differentiation function within protein families reaction mechanism those proteins enzymatically active.