Synchronization and oscillatory dynamics in heterogeneous, mutually inhibited neurons.

摘要: We study some mechanisms responsible for synchronous oscillations and loss of synchrony at physiologically relevant frequencies (10–200 Hz) in a network heterogeneous inhibitory neurons. focus on the factors that determine level frequency response, as well effects mild heterogeneity dynamics. With heterogeneity, is never perfect relatively fragile. In addition, inhibition are more complex mildly networks than homogeneous ones. former, broken two distinct ways, depending ratio synaptic decay time to period repetitive action potentials (τs/T), where T can be determined either from or single, self-inhibiting neuron. τs/T > 2, corresponding large applied current, small strength time, largely tonic neurons spike independently. < 1, breaks when faster cells begin suppress their less excitable neighbors; fire remain nearly synchronous. show numerically behavior related cells, which studied analytically.