Mercaptoacyl aminolactam endopeptidase inhibitors

摘要: Mercaptoacyl aminolactam inhibitors of endopeptidases the formula ##STR1## wherein Y is -(CHR 5 ) n (CR 3 R 4 )- or -(CR p X(CR q -, two substituents selected from group consisting , and can form a benzene, cyclopentane cyclohexane ring; X -O-, -S-, -SO- -SO 2 -; Q hydrogen 6 CO-; m 1 2; 1, 2, 4; 3; lower alkyl, aryl heteroaryl; hydrogen, hydroxylower alkoxylower aryllower alkyl heteroaryllower alkyl; are independently hydroxy, alkoxy, mercapto, alkylthio; heteroaryl, use compounds, alone in combination with an ACE inhibitor ANF, treatment cardiovascular disorders such as hypertension, congestive heart failure, edema renal insufficiency, compounds pain conditions, pharmaceutical compositions containing said disclosed.