Therapeutic Monoclonal Antibodies for the Treatment of Chronic Obstructive Pulmonary Disease

摘要: Chronic obstructive pulmonary disease (COPD) is a disorder characterized by complex chronic inflammatory response that largely poorly responsive to treatment with corticosteroids. Consequently, there huge need find effective anti-inflammatory agents for the of patients this disease. Inhibition cytokines and chemokines or their receptors using monoclonal antibodies (mAbs) could be potential strategy treat component COPD. In article, we review therapeutic some these mAbs; however, date has been little no effect any mAb directed against in This may reflect complexity COPD which dominant role single cytokine chemokine. It also likely since umbrella term covers many endotypes having different underlying mechanisms, mAbs towards specific should tested restricted focused populations.