Tumours of Soft Tissue and Bone, and Other Mesenchymal Tumours

摘要: Soft-tissue tumours are less common than epithelial or haematolymphoid neoplasms, and consequently they more likely to pose diagnostic uncertainty. Nevertheless, most soft-tissue lesions diagnosed with a satisfactory level of confidence on the basis clinical findings, histology, immunohistochemistry (IHC), cytogenetic/molecular-genetic studies. However, problem cases, where cellular differentiation may be difficult define, still encountered from time (Rampisela Donner, 2004). Partly, this is due limitations IHC: fibroblastic tumours, for instance, have poor immunoreactivity towards commonly used panels immunostains that laboratories maintain; α-smooth-muscle actin (SMA) not only stains leiomyosarcoma but also showing myofibroblastic, pericytic, endothelial cell, myoepithelial cell (specifically, in regard last group, metaplastic carcinomas). In such circumstances, electron microscopy can contribute diagnostically (Fisher, 2006; Santucci Franchi, 2008). As other groups an ultrastructural input helpful uncertainty conflicting clinical, histological immunohistochemical and, as always, fine structural data add our understanding biology tumours.