Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders
作者： Peter K. Stys , Haitao You , Gerald W. Zamponi
DOI: 10.1113/JPHYSIOL.2011.225276
关键词:
摘要: N-Methyl-D-aspartate (NMDA) receptors mediate a wide range of important nervous system functions. Conversely, excessive NMDA receptor activity leads to cytotoxic calcium overload and neuronal damage in variety CNS disorders. It is well established that are tightly regulated by number cell signalling pathways. Recently, it has been shown modulated cellular prion protein (PrP(C)) copper-dependent manner. Here we give an overview the current state knowledge concerning novel concept potent modulation this receptor's kinetics copper ions, interplay between PrP(C) context neurological diseases such as Alzheimer's disease, epilepsy, pain depression.
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