Tissue factor structure and function.

摘要: Tissue factor (TF) is an integral membrane protein that essential to life. It a component of the VIIa-TF complex enzyme and plays primary role in both normal hemostasis thrombosis. With vascular injury, TF becomes exposed blood binds plasma VIIa, resulting initiates series enzymatic reactions leading clot formation sealing. Many cells, healthy, tumor produce detectable amounts TF, especially when they are stimulated by various agents. Despite relative simplicity small size there numerous contradictory reports about synthesis presentation on cells circulation either microparticles or as soluble protein. Another subject controversy related structure/function TF. has been almost commonly accepted cell-surface-associated low (if any) activity, is, “encrypted” requires specific conditions/reagents become active, “decrypted.” However lack agreement mechanism processes alterations function. In this paper structure, presentation, function, controversies concerning these features discussed.