Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes
作者： A. W. Ford-Hutchinson , M. A. Bray , M. V. Doig , M. E. Shipley , M. J. H. Smith
DOI: 10.1038/286264A0
关键词:
摘要: Arachidonic acid is metabolised either by cyclooxygenases to produce prostaglandins and thromboxanes or lipoxygenases mono-, di- trihydroxyeicosatetraenoic acids (HETEs). Polymorphonuclear leukocytes (PMNs) release HETEs, including mono- dihydroxy fatty acids, when exposed stimuli such as the cakvim ionophore A23187 (refs 1, 2). The mono-HETEs are assumed be of particular importance with respect effects on leukocyte function because they have been shown possess both chemotactic chemokinetic activities towards PMNs eosinophils3,4. However, we now that aggregating released from rat human (ref. 5) not due but 5,12-di-HETE (leukotriene B). This compound active over concentration range 10 pg ml−1 5 ng ml−1.
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P F Weller, F F Sun, E J Goetzl, The regulation of human eosinophil function by endogenous mono-hydroxy-eicosatetraenoic acids (HETEs). Journal of Immunology. ,vol. 124, pp. 926- 933 ,(1980)
P. Borgeat, B. Samuelsson, Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds. Journal of Biological Chemistry. ,vol. 254, pp. 7865- 7869 ,(1979) , 10.1016/S0021-9258(18)36026-5
B Samuelsson, P Borgeat, Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid. Journal of Biological Chemistry. ,vol. 254, pp. 2643- 2646 ,(1979) , 10.1016/S0021-9258(17)30120-5
FIONA M. CUNNINGHAM, M. E. SHIPLEY, M. J. H. SMITH, Aggregation of rat polymorphonuclear leucocytes in vitro. Journal of Pharmacy and Pharmacology. ,vol. 32, pp. 377- 380 ,(2011) , 10.1111/J.2042-7158.1980.TB12946.X
Gary M. Bokoch, Peter W. Reed, Inhibition of the neutrophil oxidative response to A chemotactic peptide by inhibitors of arachidonic acid oxygenation Biochemical and Biophysical Research Communications. ,vol. 90, pp. 481- 487 ,(1979) , 10.1016/0006-291X(79)91260-9
W F Stenson, C W Parker, Metabolism of arachidonic acid in ionophore-stimulated neutrophils. Esterification of a hydroxylated metabolite into phospholipids. Journal of Clinical Investigation. ,vol. 64, pp. 1457- 1465 ,(1979) , 10.1172/JCI109604
P. Borgeat, B. Samuelsson, Arachidonic Acid Metabolism in Polymorphonuclear Leukocytes: Effects of Ionophore A23187 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 2148- 2152 ,(1979) , 10.1073/PNAS.76.5.2148
E J Goetzl, F F Sun, Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils. Journal of Experimental Medicine. ,vol. 150, pp. 406- 411 ,(1979) , 10.1084/JEM.150.2.406