Tumor Biology’s Impact on Clinical Cure Rates

摘要: Cure of cancer is defined as locoregional tumor control without distant metastases and life-threatening treatment complications. Radiotherapy one the main modalities. As a local treatment, its aim to achieve by inactivation all stem cells within primary regional lymph nodes. Treatment effects on are therefore focus this chapter; however, also potential indirect risk briefly considered. It well recognized that probability permanently tumors increases sigmoid function with increasing radiation dose. Below threshold, dose not sufficient inactivate in tumor, i.e. recur. After dose, approaching 100% at high doses. Even if some data suggest higher metastatic during radiotherapy, successful radiotherapy an effective way stop metastasis source, thereby importantly contributing overall survival patient. Inclusion biological parameters individual anticipated further improve results tailoring schedule, combining modern drugs, taking into account intratumoral heterogeneity based imaging.