Clinical phenotype classification for selective immunoglobulin A deficiency.

摘要: Selective immunoglobulin A deficiency (SIgAD) is the most common predominantly antibody deficiency, with a wide range of presentations from asymptomatic to severe manifestations. Although many studies have investigated different aspects SIgAD, no study has yet presented comprehensive classification this disease. Based on clinical manifestation patients and various immune abnormalities associated group could be classified into five phenotypes including asymptomatic, minor infectious, allergic, autoimmune phenotypes. This aids physicians in identifying choosing appropriate management treatment as well homogenized groups for molecular genetic studies.