Recurrent upper airway infections and bacterial biofilms.

摘要: Background: Bacterial biofilms identified in various medical devices used otorhinolaryngology, including tympanostomy tubes, voice prostheses, and cochlear implants, can directly colonise mucosal tissues. The upper airways seem to be at high risk for this type of colonisation. Chronic and/or recurrent airway infections may related the complex structural biochemical (quorum sensing) organisation biofilm which interferes with activity antibiotics (including those proven vitro efficacy), thus promoting establishment a chronic infection eradicable only by surgical treatment. Biofilm formation plays role respiratory infections: it not explains resistance these antibiotic therapy but also represents an important element that contributes maintenance inflammatory reaction. Objectives: To document presence tissue specimens from patients diseases, identify their possible chronicity infectious processes. Method: We examined 32 tract (tonsils, adenoids, mucosa ethmoid maxillary sinuses) 28 (20 adults, eight children) had persisted despite repeated treatment anti-inflammatory agents demonstrated efficacy. Tissues were cultured using conventional methods subjected scanning electron microscopy detection formation. Results: Over 80 per cent (26/32; 81.3 cent) culture-positive. (associated most cases coccoid bacteria) observed 65.6 samples.