The Effect of Low-intensity Pulsed Ultrasound on Osteogenesis in Mini-pig Mandibles

作者: Seung-Ki Min , Yeong-Eun Yun , Jun Lee , Sang-Jung Kim

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摘要: Abstract The Effect of Low-intensity Pulsed Ultrasound on Osteogenesis in Mini-pig Mandibles Yeong-Eun Yun, Jun Lee 1 , Seung-Ki Min Sang-Jung Kim Department Oral and Maxillofacial Surgery, Sun Dental Hospit al, School Dentistry, Wonkwang UniversityPurpose: objective this study was to examine the affected period amount bone formation during osteogenesis intramembranous using low-intensity pulsed ultrasound ( LPUS) vivo.Methods: Xeno-bone (Bio-oss) autogenous were grafted bilateral ly into mini-pig mandibles. left mandible served as control other treated with 3 MHz, 160 mW (output, 0.8 mW) stimulation for 7 days 15 minutes per day. mini-pigs sacrificed at 1, 2, 4, 8 weeks, micro computed tomography (μCT), a microscopic examination, statistical analysis performed specimens.Results: Based computerized image μCT scans, experimental group had an average 150% more new than that group. effect o f LPUS continued post operative 2 weeks. histomorphological examination showed similar resul ts.Conclusion: Our results suggest early intramembr anous vivo.Key words:Low-intensity ultrasound, vivo, Intramembranous bone,

参考文章(22)
Alexander Lerner, Haim Stein, How does pulsed low-intensity ultrasound enhance fracture healing? Orthopedics. ,vol. 28, pp. 1161- 1163 ,(2005) , 10.3928/0147-7447-20051001-12
[edited by] William H. Bell, Caesar A. Guerrero, Distraction Osteogenesis of the Facial Skeleton ,(2006)
Clinton Rubin, Mark Bolander, John P. Ryaby, Michael Hadjiargyrou, The use of low-intensity ultrasound to accelerate the healing of fractures. Journal of Bone and Joint Surgery, American Volume. ,vol. 83, pp. 259- 270 ,(2001) , 10.2106/00004623-200102000-00015
Hiroyuki Fujioka, Masaya Tsunoda, Mitsuaki Noda, Nobuzo Matsui, Kosaku Mizuno, Treatment of ununited fracture of the hook of hamate by low-intensity pulsed ultrasound : A case report Journal of Hand Surgery (European Volume). ,vol. 25, pp. 77- 79 ,(2000) , 10.1053/JHSU.2000.JHSU025A0077
John E. Tis, Rainer H. Meffert, Nozomu Inoue, Edward F. McCarthy, M. Shaun Machen, Kathleen A. McHale, Edmund Y. S. Chao, The effect of low intensity pulsed ultrasound applied to rabbit tibiae during the consolidation phase of distraction osteogenesis Journal of Orthopaedic Research. ,vol. 20, pp. 793- 800 ,(2002) , 10.1016/S0736-0266(02)00003-7
M. Tanzer, S. Kantor, J. D. Bobyn, Enhancement of bone growth into porous intramedullary implants using non-invasive low intensity ultrasound Journal of Orthopaedic Research. ,vol. 19, pp. 195- 199 ,(2001) , 10.1016/S0736-0266(00)00034-6
Javad Parvizi, Chi-Chuan Wu, David G. Lewallen, James F. Greenleaf, Mark E. Bolander, Low-intensity ultrasound stimulates proteoglycan synthesis in rat chondrocytes by increasing aggrecan gene expression. Journal of Orthopaedic Research. ,vol. 17, pp. 488- 494 ,(1999) , 10.1002/JOR.1100170405
C. M. Korstjens, P. A. Nolte, E. H. Burger, G. H. R. Albers, C. M. Semeins, I. H. A. Aartman, S. W. Goei, J. Klein-Nulend, Stimulation of bone cell differentiation by low-intensity ultrasound--a histomorphometric in vitro study. Journal of Orthopaedic Research. ,vol. 22, pp. 495- 500 ,(2004) , 10.1016/J.ORTHRES.2003.09.011
M. Saito, K. Fujii, T. Tanaka, S. Soshi, Effect of low- and high-intensity pulsed ultrasound on collagen post-translational modifications in MC3T3-E1 osteoblasts. Calcified Tissue International. ,vol. 75, pp. 384- 395 ,(2004) , 10.1007/S00223-004-0292-9