Bisphenol S (BPS) Alters Maternal Behavior and Brain in Mice Exposed During Pregnancy/Lactation and Their Daughters.

摘要: Estrogenic endocrine disrupting chemicals have been shown to disrupt maternal behavior in rodents. We investigated the effects of an emerging xenoestrogen, bisphenol S (BPS), on and brain CD-1 mice exposed during pregnancy lactation (F0 generation) female offspring gestation perinatal development (F1 generation). observed different F0 F1 dams for a number components behavior, including time nest, spent nest building, latency retrieve pups, entire litter. also characterized expression estrogen receptor α medial preoptic area (MPOA) quantified tyrosine hydroxylase immunoreactive cells ventral tegmental area, 2 regions critical care. BPS-treated females generation had statistically significant increase caudal subregion central MPOA dose-dependent manner. In contrast, there were no BPS or either generation. This work demonstrates that affects with outcomes depending generation, dose, postpartum period. Many studies examining view mother as means by which can be periods development. Here, we demonstrate are vulnerable mother. show developmental exposure alters later adulthood. Both findings potential public health implications.