Utility of Salivary Biomarkers for Demonstrating Acute Myocardial Infarction

摘要: The comparative utility of serum and saliva as diagnostic fluids for identifying biomarkers acute myocardial infarction (AMI) was investigated. goal to determine if salivary could facilitate a screening diagnosis AMI, especially in cases non-ST elevation MI (NSTEMI), since these are not readily identified by electrocardiogram (ECG). Serum unstimulated whole (UWS) collected from 92 AMI patients within 48 hours chest pain onset 105 asymptomatic healthy control individuals were assayed 13 proteins relevant cardiovascular disease, Beadlyte technology (Luminex(®)) enzyme immunoassays. Data analyzed with concentration cut-points, ECG findings, logistic regression (LR) (adjusted matching age, gender, race, smoking, number teeth, oral health status), classification tree (CART) analysis. A sensitivity analysis conducted repetition the CART 58 controls, each matched age gender. demonstrated specificity superior that saliva, determined LR CART. predominant discriminators troponin I (TnI), B-type natriuretic peptide (BNP), creatine kinase-MB (CK-MB), TnI BNP In C-reactive protein (CRP) biomarker most predictive AMI. combination smoking tobacco, UWS CRP, CK-MB, sCD40 ligand, teeth decision trees. When biomarkers, confounders included, predicted 80.0% 100% specificity. These analyses support potential measurements used identification Thus, saliva-based tests may provide additional information clinical course suspected having an