Water balance in very low-birth-weight infants: Relationship to water and sodium intake and effect on outcome

摘要: The clinical effects of fluid therapy designed to maintain different degrees negative water balance during the first five days life were determined prospectively in 88 very low-birth-weight infants. Infants with birth weights 750 1,500 gm matched for weight 250 increments, RDS or no RDS, asphyxiated not, and inborn outborn. Each infant was randomized either Group 1—fluids managed allow 1 2% loss BW per day a maximum 8 10%, 2—fluids 3 5% 13 15%. mean five-day cumulative input 2 220 ml/kg less than 1, yet lost only 41 gm/kg more did (8.8% vs 12.9% 2, P