Prevalence of the fragile-X syndrome in mentally retarded boys in a Swedish county
作者： Karl-Henrik Gustavson , Hans Blomquist K:son , Gösta Holmgren , John M. Opitz , James F. Reynolds
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摘要: In an etiological study of unselected series mentally retarded children (IQ less than 70) born 1959-1970 in a northern Swedish county, 12 205 boys (5.9%) were found to have fragile site on the distal end C-chromosome (fra (X) (q27]. The incidence fra syndrome was calculated be 1:1500 this county. If is true for whole Sweden, 30-40 new cases should yearly Sweden. This must considered minimum figure, since certain proportion individuals with are not observed groups patients. Next trisomy 21, X most common specific cause mental retardation among
sci-hub.se 参考文章(8)
Sutherland Gr, Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture. American Journal of Human Genetics. ,vol. 31, pp. 125- 135 ,(1979)
Diana S. Herbst, James R. Miller, Nonspecific X-linked mental retardation II: the frequency in British Columbia. American Journal of Medical Genetics. ,vol. 7, pp. 461- 469 ,(1980) , 10.1002/AJMG.1320070407
H. Kson Blomquist, K-H. Gustavson, G. Holmgren, I. Nordenson, U. Pålsson-Stråe, Fragile X syndrome in mildly mentally retarded children in a northern Swedish county. A prevalence study. Clinical Genetics. ,vol. 24, pp. 393- 398 ,(2008) , 10.1111/J.1399-0004.1983.TB00092.X
MargaretA. Leversha, GrahamC. Webb, SusanM. Pavey, CHROMOSOME BANDING REQUIRED FOR STUDIES ON X-LINKED MENTAL RETARDATION The Lancet. ,vol. 317, pp. 49- 49 ,(1981) , 10.1016/S0140-6736(81)90160-4
H. Kson Blomquist, K.-H. Gustavson, G. Holmgren, I. Nordenson, A. Sweins, Fragile site X chromosomes and X-linked mental retardation in severely retarded boys in a northern Swedish county. A prevalence study Clinical Genetics. ,vol. 21, pp. 209- 214 ,(2008) , 10.1111/J.1399-0004.1982.TB00965.X
H. KSON BLOMQUIST, K-H. GUSTAVSON, G. HOLMGREN, Severe mental retardation in children in a northern Swedish county. Journal of Intellectual Disability Research. ,vol. 25, pp. 169- 186 ,(2008) , 10.1111/J.1365-2788.1981.TB00107.X
Sutherland Gr, Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites. American Journal of Human Genetics. ,vol. 34, pp. 452- 458 ,(1982)
Gillian Turner, Ross Brookwell, Art Daniel, Mark Selikowitz, Michael Zilibowitz, Heterozygous Expression of X-Linked Mental Retardation and X-Chromosome Marker Fra(X)(Q27) New England Journal of Medicine. ,vol. 303, pp. 662- 664 ,(1980) , 10.1056/NEJM198009183031202