Effect of liquid addition on the bulk and flow properties of fine and coarse glass beads
作者： James V. Scicolone , Matthew Metzger , Sara Koynov , Kellie Anderson , Paul Takhistov
DOI: 10.1002/AIC.15004
关键词:
摘要: The effect of water on the packing and flow properties fine coarse particles was experimentally investigated. Four different particle sizes glass beads, from 5 to 275 μm, were studied with increasing weight-percentages. Using a FT4 Powder Rheometer, changes in bulk collected as function content size. results show that plays significant role particles. Small amounts created porous aggregates due liquid bridging. Greater resulted filling void-spaces. This indicated by an increase basic energy, density, pressure drop, decrease porosity. A greater understanding wetted material is useful develop standard systems can be used examine behavior more complex situations, implement improve materials handling processing. © 2015 American Institute Chemical Engineers AIChE J, 62: 648–658, 2016
sci-hub.se 参考文章(58)
Rajen D. Shah, Mohan Kabadi, David G. Pope, Larry L. Augsburger, Physico-mechanical characterization of the extrusion-spheronization process. Part II: Rheological determinants for successful extrusion and spheronization. Pharmaceutical Research. ,vol. 12, pp. 496- 507 ,(1995) , 10.1023/A:1016237509740
R ROWE, G SADEGHNEJAD, The rheology of microcrystalline cellulose powder/water mixes — measurement using a mixer torque rheometer International Journal of Pharmaceutics. ,vol. 38, pp. 227- 229 ,(1987) , 10.1016/0378-5173(87)90118-9
Chinmay Ghoroi, Lakxmi Gurumurthy, D.J. McDaniel, Laila J. Jallo, Rajesh N. Davé, Multi-faceted characterization of pharmaceutical powders to discern the influence of surface modification Powder Technology. ,vol. 236, pp. 63- 74 ,(2013) , 10.1016/J.POWTEC.2012.05.039
Changquan Calvin Sun, Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose International Journal of Pharmaceutics. ,vol. 346, pp. 93- 101 ,(2008) , 10.1016/J.IJPHARM.2007.06.017
M.D. Parker, P. York, R.C. Rowe, Binder-substrate interactions in wet granulation. 2: The effect of binder molecular weight International Journal of Pharmaceutics. ,vol. 72, pp. 243- 249 ,(1991) , 10.1016/0378-5173(91)90114-4
Pirjo Luukkonen, Torben Schæfer, Leena Hellén, Anne Mari Juppo, Jouko Yliruusi, Rheological characterization of microcrystalline cellulose and silicified microcrystalline cellulose wet masses using a mixer torque rheometer. International Journal of Pharmaceutics. ,vol. 188, pp. 181- 192 ,(1999) , 10.1016/S0378-5173(99)00219-7
S. M. Iveson, J. D. Litster, Growth regime map for liquid-bound granules Aiche Journal. ,vol. 44, pp. 1510- 1518 ,(1998) , 10.1002/AIC.690440705
K. E. FIELDEN, J. M. NEWTON, R. C. ROWE, The effect of lactose particle size on the extrusion properties of microcrystalline cellulose-lactose mixtures. Journal of Pharmacy and Pharmacology. ,vol. 41, pp. 217- 221 ,(2011) , 10.1111/J.2042-7158.1989.TB06438.X
M.D. Parker, P. York, R.C. Rowe, Binder-substrate interactions in wet granulation. 3: The effect of excipient source variation International Journal of Pharmaceutics. ,vol. 80, pp. 179- 190 ,(1992) , 10.1016/0378-5173(92)90276-8
E. Rondet, M. Delalonde, T. Ruiz, J.P. Desfours, Identification of granular compactness during the kneading of a humidified cohesive powder Powder Technology. ,vol. 191, pp. 7- 12 ,(2009) , 10.1016/J.POWTEC.2008.09.004