Statins and Lung Cancer: A Review of Current Literature

Weitberg Ab, The Antioxidant Effect of Lovastatin on Phagocyte-Induced DNA Damage : Implications for Cancer Prevention Journal of Experimental & Clinical Cancer Research. ,vol. 26, pp. 583- 586 ,(2007)

Aleksandra A. Pandyra, Peter J. Mullen, Carolyn A. Goard, Elke Ericson, Piyush Sharma, Manpreet Kalkat, Rosemary Yu, Janice T. Pong, Kevin R. Brown, Traver Hart, Marinella Gebbia, Karl S. Lang, Guri Giaever, Corey Nislow, Jason Moffat, Linda Z. Penn, Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death Oncotarget. ,vol. 6, pp. 26909- 26921 ,(2015) , 10.18632/ONCOTARGET.4817

Inger H. Madshus, Frøydis D. Blystad, Finn O. Levy, Espen Stang, Tove Ringerike, Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae Journal of Cell Science. ,vol. 115, pp. 1331- 1340 ,(2002) , 10.1242/JCS.115.6.1331

Jie Chen, Bing Liu, Jiayi Yuan, Jie Yang, Jingjie Zhang, Yu An, Lu Tie, Yan Pan, Xuejun Li, Atorvastatin reduces vascular endothelial growth factor (VEGF) expression in human non-small cell lung carcinomas (NSCLCs) via inhibition of reactive oxygen species (ROS) production Molecular Oncology. ,vol. 6, pp. 62- 72 ,(2012) , 10.1016/J.MOLONC.2011.11.003

Jaana Kuoppala, Anne Lamminpää, Eero Pukkala, Statins and cancer: A systematic review and meta-analysis European Journal of Cancer. ,vol. 44, pp. 2122- 2132 ,(2008) , 10.1016/J.EJCA.2008.06.025

Brendan D. Manning, Lewis C. Cantley, AKT/PKB signaling: navigating downstream. Cell. ,vol. 129, pp. 1261- 1274 ,(2007) , 10.1016/J.CELL.2007.06.009

Susumu Kobayashi, Lewis C. Cantley, Pankaj Seth, Vikas P. Sukhatme, Jun-ichi Hanai, Nathaniel Doro, Atsuo T. Sasaki, Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways† Journal of Cellular Physiology. ,vol. 227, pp. 1709- 1720 ,(2012) , 10.1002/JCP.22895

DAVID JOHN GARNETT, TREVOR JAMES GREENHOUGH, Statins cause profound effects on gene expression in human cancer cells in vitro: the role of membrane microdomains. Gene Expression. ,vol. 15, pp. 225- 234 ,(2013) , 10.3727/105221613X13571653093240

Luca Gallelli, Daniela Falcone, Monica Scaramuzzino, Girolamo Pelaia, Bruno D’Agostino, Maria Mesuraca, Rosa Terracciano, Giuseppe Spaziano, Rosario Maselli, Michele Navarra, Rocco Savino, Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide BMC Clinical Pharmacology. ,vol. 15, pp. 67- 67 ,(2014) , 10.1186/2050-6511-15-67

Toran Sanli, Caiqiong Liu, Ayesha Rashid, Sarah N. Hopmans, Evangelia Tsiani, Carrie Schultz, Thomas Farrell, Gurmit Singh, James Wright, Theodoros Tsakiridis, Lovastatin Sensitizes Lung Cancer Cells to Ionizing Radiation: Modulation of Molecular Pathways of Radioresistance and Tumor Suppression Journal of Thoracic Oncology. ,vol. 6, pp. 439- 450 ,(2011) , 10.1097/JTO.0B013E3182049D8B