Oscillation mechanics of the human lung periphery in asthma

摘要: To more precisely measure the mechanical properties of lung periphery in asthma, we have developed a forced oscillation technique that applies broad-band flow signal through wedged bronchoscope. We interpreted data from four healthy and eight mildly asthmatic subjects terms an anatomically accurate computer model segment. There was substantial overlap impedance between two groups, with resistance (R) showing minimal frequency dependence elastance (E) positive negative across subjects. After direct instillation methacholine, R rose both but compared subjects, displayed upward, parallel shifts their dose-response curves. The baseline frequency-response patterns E were enhanced after methacholine. Frequency dependencies well reproduced normal by computational employed rigid airways connected to constant-phase tissue units better other three when heterogeneous, peripheral airway narrowing compliant airways. capture remaining five modified increasing wall stiffness. These results indicate is not distinguished measurement at baseline, group differences are seen challenge Modeling response suggests variable contributions compliance operative determining overall humans likely reflecting functional consequences inflammation remodeling.