The Current State of Biological and Clinical Implications of Human Papillomavirus-Related Oropharyngeal Cancer

摘要: In the effort to control human papillomavirus-related oropharyngeal cancer, head and neck oncology community has devoted much understanding its disease biology clinical behavior, refining strategies address early diagnosis optimal management for affected population. This review identifies articles published up March 2017 on tumor implications of summarizes findings in some key areas. These include potential screening strategies, possible anatomical features responsible lymph node involvement implication staging, biological mechanisms explain superior outcomes compared traditional nonviral-related mucosal cancers, re-appreciation prognostic factors (eg, hypoxia, extranodal extension, smoking), current efforts optimize this patient The reflects global mitigate influence burgeoning disease.