The circadian variation of catecholamine metabolism in the subhuman primate

摘要: Abstract Cerebrospinal fluid (CSF) was removed continuously in 2- or 3-h aliquots from the lateral and fourth cerebral ventricles of chronic chair restrained rhesus monkeys. Under conditions 12 h light (06.00–18.00 h) darkness (18.00-06.00 concentrations norepinephrine (NE) were found to describe a circadian pattern, with maximal occurring during hours minimal dark hours. The patterns generally coincident brain temperature body activity. When assayed for 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) 3-methoxy-4-hydroxymandelic acid (VMA), samples CSF collected over 3–4 days demonstrated no reproducible pattern change. Fluctuation concentration MHPG did not correspond direction magnitude changes VMA. These random fluctuations may part be accounted by influx metabolites peripheral sources CSF, relatively slow movement these as they diffuse parenchyma CSF.