Galectin-1 promotes immunoglobulin production during plasma cell differentiation
作者： Chih-Ming Tsai , Yi-Kai Chiu , Tsui-Ling Hsu , I-Ying Lin , Shie-Liang Hsieh
DOI: 10.4049/JIMMUNOL.181.7.4570
关键词:
摘要: Galectin-1, a β-galactoside-binding soluble lectin, has been implicated in regulating immune system homeostasis. We investigated the function of galectin-1 plasma cell differentiation and found that it is induced primary murine human differentiating B cells. lymphocyte-induced maturation protein-1 (Blimp-1), master regulator for differentiation, was necessary sufficient to induce expression. Notably, ectopic expression mature cells increased Ig μ-chain transcript levels as well overall level production. This dependent on binding surface glycosylated counter receptors, mutant deficient β-galactoside showed diminished ability promote Extracellular bound more significantly than Lastly, we sugar compound N -acetyllactosamine blocked splenic inhibited their differentiation. Taken together, these data are first demonstrate role promoting production during
jimmunol.org参考文章(48)
Brianna N. Stillman, Daniel K. Hsu, Mabel Pang, C. Fred Brewer, Pauline Johnson, Fu-Tong Liu, Linda G. Baum, Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death. Journal of Immunology. ,vol. 176, pp. 778- 789 ,(2006) , 10.4049/JIMMUNOL.176.2.778
Janet F. Piskurich, Kuo -I. Lin, Yi Lin, Ying Wang, Jenny P. -Y. Ting, Kathryn Calame, BLIMP-1 mediates extinction of major histocompatibility class II transactivator expression in plasma cells Nature Immunology. ,vol. 1, pp. 526- 532 ,(2000) , 10.1038/82788
H Leffler, S H Barondes, Specificity of binding of three soluble rat lung lectins to substituted and unsubstituted mammalian beta-galactosides. Journal of Biological Chemistry. ,vol. 261, pp. 10119- 10126 ,(1986) , 10.1016/S0021-9258(18)67499-X
J. Hirabayashi, K. Kasai, Effect of amino acid substitution by sited-directed mutagenesis on the carbohydrate recognition and stability of human 14-kDa beta-galactoside-binding lectin. Journal of Biological Chemistry. ,vol. 266, pp. 23648- 23653 ,(1991) , 10.1016/S0021-9258(18)54333-7
Yung-Chi Chang, Yueh-Hsuan Chan, David G. Jackson, Shie-Liang Hsieh, The glycosaminoglycan-binding domain of decoy receptor 3 is essential for induction of monocyte adhesion. Journal of Immunology. ,vol. 176, pp. 173- 180 ,(2006) , 10.4049/JIMMUNOL.176.1.173
Jennifer A. Fulcher, Sara T. Hashimi, Ernest L. Levroney, Mabel Pang, Kevin B. Gurney, Linda G. Baum, Benhur Lee, Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix. Journal of Immunology. ,vol. 177, pp. 216- 226 ,(2006) , 10.4049/JIMMUNOL.177.1.216
M. Moran, K. R. Kozak, J. T. Nguyen, M. C. Miceli, L. A. Lewis, L. G. Baum, G. N. R. Vespa, Galectin-1 Specifically Modulates TCR Signals to Enhance TCR Apoptosis but Inhibit IL-2 Production and Proliferation Journal of Immunology. ,vol. 162, pp. 799- 806 ,(1999)
Benjamin Rossi, Marion Espeli, Claudine Schiff, Laurent Gauthier, Clustering of Pre-B Cell Integrins Induces Galectin-1-Dependent Pre-B Cell Receptor Relocalization and Activation Journal of Immunology. ,vol. 177, pp. 796- 803 ,(2006) , 10.4049/JIMMUNOL.177.2.796
A.L. Shaffer, Kuo-I Lin, Tracy C. Kuo, Xin Yu, Elaine M. Hurt, Andreas Rosenwald, Jena M. Giltnane, Liming Yang, Hong Zhao, Kathryn Calame, Louis M. Staudt, Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program Immunity. ,vol. 17, pp. 51- 62 ,(2002) , 10.1016/S1074-7613(02)00335-7
Jenny Almkvist, Anna Karlsson, Galectins as inflammatory mediators Glycoconjugate Journal. ,vol. 19, pp. 575- 581 ,(2002) , 10.1023/B:GLYC.0000014088.21242.E0