Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition
作者： Mara Ferrandi , Paolo Barassi , Francesco Tadini-Buoninsegni , Gianluca Bartolommei , Isabella Molinari
DOI: 10.1111/BPH.12278
关键词:
摘要: Background and Purpose Calcium handling is known to be deranged in heart failure. Interventions aimed at improving cell Ca2+ cycling may represent a promising approach failure therapy. Istaroxime new luso-inotropic compound that stimulates cardiac contractility relaxation healthy failing animal models patients with acute (AHF) syndrome. Na-K ATPase inhibitor the unique property of increasing sarcoplasmic reticulum (SR) SERCA2a activity as shown microsomes from humans guinea pigs. The present study addressed molecular mechanism by which istaroxime increases activity.
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