Marijuana use is associated with worse outcomes in symptom severity and violent behavior in patients with posttraumatic stress disorder.

作者: Samuel T. Wilkinson , Elina Stefanovics , Robert A. Rosenheck

DOI: 10.4088/JCP.14M09475

关键词:

摘要: OBJECTIVE: An increasing number of states have approved posttraumatic stress disorder (PTSD) as a qualifying condition for medical marijuana, although little evidence exists evaluating the effect marijuana use in PTSD. We examined association between and PTSD symptom severity longitudinal, observational study. METHOD: From 1992 to 2011, veterans with DSM-III/-IV (N = 2,276) were admitted specialized Veterans Affairs treatment programs, assessments conducted at intake 4 months after discharge. Subjects classified into groups according use: those no admission or discharge ("never-users"), who used but not ("stoppers"), ("continuing users"), using ("starters"). Analyses variance compared baseline characteristics identified relevant covariates. covariance then on follow-up measures symptoms, drug alcohol use, violent behavior, employment. RESULTS: After we adjusted covariates, was significantly associated worse outcomes (P CONCLUSIONS: In this study, initiating more use. Marijuana may actually worsen symptoms nullify benefits specialized, intensive treatment. Cessation prevention be an important goal Language: en

参考文章(37)
Felice Carabellese, Donatella La Tegola, Chiara Candelli, Domenico Martinelli, Roberto Catanesi, Cannabis use and violent behaviour: a psychiatric patients cohort study in Southern Italy. Rivista Di Psichiatria. ,vol. 48, pp. 43- 50 ,(2013) , 10.1708/1228.13614
Matthew Tyler Boden, Kimberly A. Babson, Anka A. Vujanovic, Nicole A. Short, Marcel O. Bonn-Miller, Posttraumatic stress disorder and cannabis use characteristics among military veterans with cannabis dependence. American Journal on Addictions. ,vol. 22, pp. 277- 284 ,(2013) , 10.1111/J.1521-0391.2012.12018.X
A. W. Zuardi, R. A. Cosme, F. G. Graeff, F. S. Guimarães, Effects of ipsapirone and cannabidiol on human experimental anxiety. Journal of Psychopharmacology. ,vol. 7, pp. 82- 88 ,(1993) , 10.1177/026988119300700112
Torsten Passie, Hinderk M. Emrich, Matthias Karst, Simon D. Brandt, John H. Halpern, Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence Drug Testing and Analysis. ,vol. 4, pp. 649- 659 ,(2012) , 10.1002/DTA.1377
Cristina AJ Stern, Lucas Gazarini, Reinaldo N Takahashi, Francisco S Guimarães, Leandro J Bertoglio, None, On disruption of fear memory by reconsolidation blockade: evidence from cannabidiol treatment. Neuropsychopharmacology. ,vol. 37, pp. 2132- 2142 ,(2012) , 10.1038/NPP.2012.63
Samuel T. Wilkinson, Deepak Cyril D’Souza, Problems With the Medicalization of Marijuana JAMA. ,vol. 311, pp. 2377- 2378 ,(2014) , 10.1001/JAMA.2014.6175
Jesse R Cougle, Marcel O Bonn-Miller, Anka A Vujanovic, Michael J Zvolensky, Kirsten A Hawkins, None, Posttraumatic stress disorder and cannabis use in a nationally representative sample. Psychology of Addictive Behaviors. ,vol. 25, pp. 554- 558 ,(2011) , 10.1037/A0023076
José Alexandre Crippa, Antonio Waldo Zuardi, Rocio Martín-Santos, Sagnik Bhattacharyya, Zerrin Atakan, Philip McGuire, Paolo Fusar-Poli, Cannabis and anxiety: a critical review of the evidence Human Psychopharmacology-clinical and Experimental. ,vol. 24, pp. 515- 523 ,(2009) , 10.1002/HUP.1048
Alan J. Budney, Brent A. Moore, Ryan G. Vandrey, John R. Hughes, The time course and significance of cannabis withdrawal. Journal of Abnormal Psychology. ,vol. 112, pp. 393- 402 ,(2003) , 10.1037/0021-843X.112.3.393