Comparison of Lives Saved Tool model child mortality estimates against measured data from vector control studies in sub-Saharan Africa

摘要: Background: Insecticide-treated mosquito nets (ITNs) and indoor-residual spraying have been scaled-up across sub-Saharan Africa as part of international efforts to control malaria. These interventions the potential significantly impact child survival. The Lives Saved Tool (LiST) was developed provide national regional estimates cause-specific mortality based on extent intervention coverage scale-up. We compared percent reduction in all-cause estimated by LiST against measured reductions from studies assessing vector Africa. Methods: performed a literature search for appropriate 4 that changes following scale-up interventions. key parameters each study were applied available country projections: baseline rate, proportion due malaria, population at follow-up years. Results: model fell within confidence intervals around all studies. Two overestimated 6.1 4.2 percentage points (33% 35% relative estimates), while two underestimated 4.7 6.2 (22% 25% estimates). Conclusions: did not systematically under- or overestimate ITNs mortality. results show perform reasonably well estimating effect when data range malaria transmission settings. appears be useful tool achieved scaling-up