What we know so far about Coronavirus Disease 2019 in children: A meta-analysis of 551 laboratory-confirmed cases.

摘要: Aim To summarize what we know so far about coronavirus disease (COVID-19) in children. Method We searched PubMed, Scientific Electronic Library Online, and Latin American Caribbean Center on Health Sciences Information from 1 January 2020 to 4 May 2020. selected randomized trials, observational studies, case series or reports, research letters of children ages birth 18 years with laboratory-confirmed COVID-19. conducted random-effects meta-analyses calculate the weighted mean prevalence 95% confidence interval (CI) average means CI. Result Forty-six articles reporting 551 cases COVID-19 (aged day-17.5 years) were included. Eighty-seven percent (95% CI: 77%-95%) patients had household exposure The most common symptoms signs fever (53%, 45%-61%), cough (39%, 30%-47%), sore throat/pharyngeal erythema (14%, 4%-28%); however, 18% 11%-27%) asymptomatic. radiographic computed tomography (CT) findings patchy consolidations (33%, 23%-43%) ground glass opacities (28%, 18%-39%), but 36% 28%-45%) normal CT images. Antiviral agents given 74% 52%-92%). Six patients, all major underlying medical conditions, needed invasive mechanical ventilation, one them died. Conclusion Previously healthy have mild symptoms. diagnosis is generally suspected history case. Children condition are more likely severe/critical poor prognosis, even death.