Comparative Pathology of Canine Soft Tissue Sarcomas: Possible Models of Human Non-rhabdomyosarcoma Soft Tissue Sarcomas

摘要: Comparative analyses of canine and human soft tissue sarcomas (STSs) are lacking. This study compared the histological immunohistochemical (labelling for desmin, smooth muscle actin [SMA], CD31, pancytokeratin, S100 CD34) appearance 32 archived, formalin-fixed, paraffin wax-embedded STS tumour specimens by board-certified veterinary medical pathologists, both blinded to other's interpretations. Comparison between diagnoses revealed a generally consistent pattern interpretation with few notable variations. Most tumours (13/32) were judged display similar histomorphological low-grade spindle cell sarcomas, appearing non-distinctive morphologically fibroblastic/myofibroblastic type. Five cases resembled liposarcoma, but atypical desmin-positive epithelioid cells present. sarcoma myxoid features two additional myxofibrosarcoma. Seven noted resemble undifferentiated sarcoma. Findings in present demonstrate that STSs their equivalents. Because these cross-species similarities, particular opportunity exists understand biology treatment potentially including dogs as clinical models.